įurthermore, statins inhibit the enzyme HMG-CoA reductase at a stage early in the mevalonate pathway. Statin drugs include (Atorvastatin, Simvastatin, Pravastatin, Pitavastatin, Lovastatin and Rosuvastatin) and are perceived to have a favourable safety profile. Statins as drug therapy inhibit the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase are considered the most effective class of drugs for the treatment of dyslipidemia. However, numerous comprehensive studies support the use of statins in coronary heart disease (CHD) patients for the treatment of dyslipidemia and secondary prevention. Lifestyle modifications and other pharmacological interventions that lower blood cholesterol (such as statins) have been shown to reduce the incidence and frequency of major coronary artery events and overall mortality associated with dyslipidemia. reported that lifestyle modification could also help this aspect. As a non-pharmacological treatment, Jena et al. However, several pharmacological and non-pharmacological approaches have been recommended to treat and reduce hyperlipidaemia’s risk during the past three decades. It was estimated that the total cost of CVD and stroke associated with dyslipidemia – exceeds $400 million in a study conducted in the USA in 2006. Previous studies suggested that the financial ‘direct and indirect’ cost of lipid stiffness places a heavy burden on health service financing sources worldwide. Furthermore, the World Health Organization reports indicated that in 2030, the number of deaths could reach 23.6 million from CVD. However, dyslipidemia is classified as a modifiable risk factor for the incidence and development of cardiovascular diseases (CVD). triglycerides, cholesterol and fat phospholipids) in the blood. Dyslipidemia refers to the abnormal amounts of lipids (e.g. It has long been recognized as one of the highest leading causes of death worldwide. Clinical pharmacist, statins, drug interactions, rational medication use, awareness Introductionĭyslipidemia is a broad term that refers to several lipid disorders.
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